HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilyldiazomethane → 2-Tert-butoxycarbonylamino-4-hydroxy-butyric acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | 2-(((Tert-butoxy)carbonyl)amino)-4-hydroxybutanoic acid | HCID 4118627 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Tert-butoxycarbonylamino-4-hydroxy-butyric acid methyl ester | HCID 6857809 | — |
Reaction Steps
2-tert-Butoxycarbonylamino-4-hydroxy-butyric acid (0.79 g, 3.6 mmol) was dissolved in 15 ml methanol at room temperature and (trimethylsilyl)diazomethane (2M solution in hexane) was added till solution become yellow. The mixture was concentrated down to afford crude 2-tert-butoxycarbonylamino-4-hydroxy-butyric acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07504508B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-5ce92dc187844cc28977b7bd81bea19d |
| Source note | uspto-grants-2009_03 |