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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1786106Generated: October 31, 2026

9-Bromo-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one → 4-Chloro-2-(5-phenyl-2H-[1,2,4]triazol-3-yl)-phenylamine

https://huagongshe.com/reaction/1786106

Reaction equation

Participants

RoleNameHCIDCharge
Reactant9-Bromo-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-oneHCID 135766855—
Reactant9-Chloro-2-phenyl[1,2,4]triazolo[1,5-c]quinazolin-5(3H)-oneHCID 135778278—
Product4-Chloro-2-(5-phenyl-2H-[1,2,4]triazol-3-yl)-phenylamineHCID 1403186792.3%

Reaction Steps

As described for example 21c) 9-chloro-2-phenyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one (6.34 g, 21.4 mmol), instead of 9-bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one, was converted to the title compound (5.35 g, 92%) which was obtained as a light brown solid. MS: m/e=271.0 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07507728B2
Source datasetuspto-grants-2009_03
ORD IDord-5fb367e94c204c03a78477838c1bb55b
Source noteuspto-grants-2009_03