反应详情

To a solution of N-{[(5R)-16-(dimethylamino)-4-oxo-2,3,15,17,18-pentaazabicyclo[12.3.1]octadeca-1(18),10,14,16-tetraen-5-yl]methyl}-N-benzoxyformamide (75 mg) in MeOH (15 mL) was added 10% Pd/C (15 mg, 20% w/w). The reaction mixture was subjected to hydrogenation for 3 hours at room temperature. The reaction mixture was then filtered through a pad of Celite, and washed with MeOH (10 mL×2). Removal of the solvent provided the title compound. MH+380.

1. filtrationThe reaction mixture was then filtered through a pad of Celite
2. washwashed with MeOH (10 mL×2)
3. customRemoval of the solvent