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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1786125Generated: November 2, 2026

3-Ethoxy-2-propenenitrile → 2-(Propan-2-yl)pyrimidin-4-amine

https://huagongshe.com/reaction/1786125

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Ethoxy-2-propenenitrileHCID 43601—
ReactantCyclopropanecarboximidamide hydrochlorideHCID 2781916—
Product2-(Propan-2-yl)pyrimidin-4-amineHCID 13925297—

Reaction Steps

This compound was made in analogy to example 2, step A] from cyclopropylcarbamidine hydrochloride (3 g) and 3-ethoxyacrylonitrile (2.5 mL) to give 2-isopropyl-pyrimidin-4-ylamine (1.36 g) as a light yellow foam. MS (ESI): 138.1 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07507733B2
Source datasetuspto-grants-2009_03
ORD IDord-3978ef0eda0643959c59e96f9ced050e
Source noteuspto-grants-2009_03