HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 2-(3,5-Dimethyl-1H-pyrazol-4-yl)acetohydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | ethyl 2-(3,5-dimethyl-1H-pyrazol-4-yl)acetate | HCID 16394806 | — |
| Reactant | 2-(1H-pyrazol-4-yl)acetic acid | HCID 20555351 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 2-(3,5-Dimethyl-1H-pyrazol-4-yl)acetohydrazide | HCID 43236691 | 68% |
Reaction Steps
As described for example 112a, (3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid ethyl ester (Rainer, Georg. 4-Pyrazoleacetic acid derivatives. U.S. (1979), U.S. Pat. No. 4,146,721) in butanol was reacted with hydrazine hydrate (3 equivalents) and the resulting mixture was heated under reflux for 6 h. Evaporation of all volatiles afforded the title compound as a colourless oil (yield: 68%). MS: m/e=183.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07507729B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-631d905e8e454e15aa32371b58415fcf |
| Source note | uspto-grants-2009_03 |