HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 2-(3-Methyl-2-oxopyridin-1(2H)-yl)acetohydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | (3-Methyl-2-oxo-2H-pyridin-1-yl)-acetic acid ethyl ester | HCID 22943407 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(3-Methyl-2-oxopyridin-1(2H)-yl)acetohydrazide | HCID 63579247 | 96% |
Reaction Steps
As described for example 112a, (3-methyl-2-oxo-2H-pyridin-1-yl)-acetic acid ethyl ester in ethanol was reacted with hydrazine hydrate (1.2 equivalents) at rt for 72 h. The mixture was concentrated and crystallized from ethanol/diisopropylether and the compound was obtained as a white solid (yield: 96%). MS: m/e=204.4 [M+Na]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07507729B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-3a53b2c8fed641548f22ade3e5cfc361 |
| Source note | uspto-grants-2009_03 |