Hydrogen Bromide → HCID 178476734, compound

Participants

Reaction Conditions

Reaction Steps

The product of step (a) (207 g, 0.492 mol) was slurried in acetic acid (3100 ml) and heated to 60° C. 48% Hydrobromic acid (4.93 mol) was added dropwise keeping the temperature at 60° C. The solution was stirred at 60° C. for 30 minutes. Water (700 ml) was added dropwise keeping the temperature above 55° C. The slurry was cooled to 20° C. and stirred for a further 30 minutes after which it was filtered, washed with acetic acid:water (2000 ml) and water (1000 ml) before being dried in a vacuum oven overnight at 60° C. to yield a white solid of the title compound as an acetic acid solvate (153.6 g, 73.5%).

Provenance & Evidence