反应详情

The product of Example 2 is dissolved in 10% methyl alcohol in methylene chloride (150 mL) and filtered. To the filtrate is bubbled hydrogen chloride gas. Concentration provides 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine hydrogen chloride salt as a light yellow solid (2.92 g).

1. filtrationfiltered
2. customTo the filtrate is bubbled hydrogen chloride gas
3. concentrationConcentration