Morpholine → HCID 58932632, compound

Participants

Reaction Conditions

Reaction Steps

(S)-toluene-4-sulfonic acid 2-hydroxy-4,4-dimethyl-pentyl ester obtained from Example 4, step A (700 mg, 2.4 mmol) was charged to a large microwave reactor vial and treated with morpholine (3 mL). The vial was crimped shut and heated to 160° C. for 6 minutes. The solvent was then removed. The resulting oil was dissolved in ethyl acetate and extracted 3 time with aqueous 1 M HCl. The organics were discarded and the aqueous layer was made basic with solid NaOH and extracted 3 times with ethyl acetate. The organic extracts were combined, dried over MgSO4 and the solvent was removed to afford 330 mg (67%) of material which was used without further purification: HPLC-MS calcd. for C11H23NO2 (M+H+) 202.2, found 202.5.

Provenance & Evidence