1-Bromopropane → HCID 11254961, compound

HRID 1786446Notes

Reaction equation

HRID 1786446 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[N:11]([CH3:16])[C:12]([SH:15])=[N:13][CH:14]=2)[OH:9])=[CH:4][CH:3]=1.Br[CH2:18][CH2:19][CH3:20]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:10]2[N:11]([CH3:16])[C:12]([S:15][CH2:18][CH2:19][CH3:20])=[N:13][CH:14]=2)[OH:9])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 78401-BromopropaneHCID 178481122HCID 178481122, compound

Product 1

HCID 11254961HCID 11254961, compoundYield 71%

Procedure

The product of Example I, Step A (3.35 g) was subjected to the same conditions as described in Example I, Step B except that bromopropane (1.4 mL) was employed as the alkylating agent to provide (4-Chlorophenyl)-(3-methyl-2-propylsulfanyl-3H-imidazol-4-yl)-methanol (2.69 g, 71%). M calc=296; M+H found=297. Calculated for C14H17N2OSCl: C 56.65, H 5.77, 9.44; found C 55.88, H 5.88, N 9.84.

Sources & evidence

ORD record
ord-7cf15beb6df540968fa3d3aaa5a6be29
Source dataset
uspto-grants-2009_03
Patent number
US07507756B2

Reaction notes

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