HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → [6-Bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(4-trifluoromethanesulfonyl-piperazin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Trifluoromethanesulfonyl chloride | HCID 79000 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 1-((Trifluoromethyl)sulfonyl)piperazine | HCID 18690833 | — |
| Reactant | 6-bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid | HCID 67017931 | — |
| Product | [6-Bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(4-trifluoromethanesulfonyl-piperazin-1-yl)-methanone | HCID 68565282 | 48% |
Reaction Steps
The title compound was synthesized in analogy to example 1, from 6-bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid; hydrochloride (example 1, intermediate a) and 1-trifluoromethanesulfonyl-piperazine (prepared in analogy to International Patent Application Publ. No. WO 2003/064413 by using trifluoromethanesulfonyl chloride and tert-butyl 1-piperazinecarboxylate) to afford the title compound as a yellow solid (48%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07507736B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-3ebb0e6b7e434129bfef22e8e0b9d4cf |
| Source note | uspto-grants-2009_03 |