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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1786464Generated: October 26, 2026

1-(Methylsulfonyl)piperazine → [5-(1-Isopropyl-piperidin-4-yloxy)-6-methyl-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanone

https://huagongshe.com/reaction/1786464

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Methylsulfonyl)piperazineHCID 709161—
Reactant5-(1-isopropyl-piperidin-4-yloxy)-6-methyl-1H-indole-2-carboxylic acid hydrochlorideHCID 68563636—
Product[5-(1-Isopropyl-piperidin-4-yloxy)-6-methyl-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanoneHCID 6856367949%

Reaction Steps

The title compound was synthesized in analogy to example 1, from 5-(1-isopropyl-piperidin-4-yloxy)-6-methyl-1H-indole-2-carboxylic acid hydrochloride and 1-methanesulfonylpiperazine to afford the title compound as a light-yellow solid (49%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07507736B2
Source datasetuspto-grants-2009_03
ORD IDord-045bbf6a327c481b8dd1b5f284784d98
Source noteuspto-grants-2009_03