Boron tribromide → HCID 68564618, compound

Participants

Reaction Steps

A solution of 0.13 g (0.56 mmol) 5-methoxy-6-methyl-1H-indole-2-carboxylic acid ethyl ester in 3 mL dichloromethane was cooled to −78° C. 1.11 mL (1.1 mmol, 1 M solution in dichloromethane) boron tribromide were added and the cooling bath was removed. After stirring 2 h at room temperature, the solution was poured into 10% aqueous sodium bicarbonate solution and the phases were separated. The aqueous layer was extracted three times with ethyl acetate and the combined organic layers were washed with brine, dried over magnesium sulfate, filtered and evaporated. The residue was purified by flash chromatography on silica gel using a gradient of n-heptane: ethyl acetate (100:0 to 70:30 v/v) as eluant, to afford 53 mg (43%) of the title compound as a light-yellow solid.

Provenance & Evidence