1-(Cyclopropylcarbonyl)piperazine → (4-Cyclopropanecarbonyl-piperazin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-6-methyl-1H-indol-2-yl]-methanone

HRID 1786470Notes

Reaction equation

HRID 1786470 reaction equation
Cl.[CH:2]([N:5]1[CH2:10][CH2:9][CH:8]([O:11][C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][C:20]=2[CH3:21])[NH:17][C:16]([C:22]([OH:24])=O)=[CH:15]3)[CH2:7][CH2:6]1)([CH3:4])[CH3:3].[CH:25]1([C:28]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)=[O:29])[CH2:27][CH2:26]1>>[CH:25]1([C:28]([N:30]2[CH2:35][CH2:34][N:33]([C:22]([C:16]3[NH:17][C:18]4[C:14]([CH:15]=3)=[CH:13][C:12]([O:11][CH:8]3[CH2:9][CH2:10][N:5]([CH:2]([CH3:3])[CH3:4])[CH2:6][CH2:7]3)=[C:20]([CH3:21])[CH:19]=4)=[O:24])[CH2:32][CH2:31]2)=[O:29])[CH2:26][CH2:27]1

Participants

3

Reactant 2

HCID 20642351-(Cyclopropylcarbonyl)piperazineHCID 685636365-(1-isopropyl-piperidin-4-yloxy)-6-methyl-1H-indole-2-carboxylic acid hydrochloride

Product 1

HCID 68565372(4-Cyclopropanecarbonyl-piperazin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-6-methyl-1H-indol-2-yl]-methanoneYield 56%

Procedure

The title compound was synthesized in analogy to example 1, from 5-(1-isopropyl-piperidin-4-yloxy)-6-methyl-1H-indole-2-carboxylic acid hydrochloride and 1-(cyclopropanecarbonyl)piperazine to afford the title compound as a light-yellow foam (56%).

Sources & evidence

ORD record
ord-9f84cf9092984fa5987f0277e691be2b
Source dataset
uspto-grants-2009_03
Patent number
US07507736B2

Reaction notes

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