HRID1786471

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10796

Cesium carbonate

CCs2O3

HCID13551

Isopropyl methanesulfonate

C4H10O3S

结构：Cc1cc2[nH]c(C(=O)N3CCN(S(C)(=O)=O)CC3)cc2cc1OC1CCN(C(C)C)CC1

HCID68563679

未命名化合物

PRODUCTS

生成物

结构：Cc1cc2c(cc1OC1CCN(C(C)C)CC1)cc(C(=O)N1CCN(S(C)(=O)=O)CC1)n2C(C)C

HCID68565510

未命名化合物

收率 9%

PROCEDURE

实验过程

The title compound was synthesized in analogy to example 4, from [5-(1-isopropyl-piperidin-4-yloxy)-6-methyl-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanone (example 29), cesium carbonate and isopropyl methanesulfonate, to afford the title compound as a light-yellow oil (9%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-181aad76998c4b76a9cc21cbd335fd4f
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07507736B2
来源说明: uspto-grants-2009_03

反应 SMILES

[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([O:10][C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][C:19]=2[CH3:20])[NH:16][C:15]([C:21]([N:23]2[CH2:28][CH2:27][N:26]([S:29]([CH3:32])(=[O:31])=[O:30])[CH2:25][CH2:24]2)=[O:22])=[CH:14]3)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].C(=O)([O-])[O-].[Cs+].[Cs+].CS(O[CH:44]([CH3:46])[CH3:45])(=O)=O>>[CH:44]([N:16]1[C:17]2[C:13](=[CH:12][C:11]([O:10][CH:7]3[CH2:8][CH2:9][N:4]([CH:1]([CH3:2])[CH3:3])[CH2:5][CH2:6]3)=[C:19]([CH3:20])[CH:18]=2)[CH:14]=[C:15]1[C:21]([N:23]1[CH2:24][CH2:25][N:26]([S:29]([CH3:32])(=[O:31])=[O:30])[CH2:27][CH2:28]1)=[O:22])([CH3:46])[CH3:45]