HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoroethanesulfonyl chloride → [5-(1-Isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-[4-(2,2,2-trifluoro-ethanesulfonyl)-piperazin-1-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoroethanesulfonyl chloride | HCID 74242 | — |
| Reactant | [5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-piperazin-1-yl-methanone dihydrochloride | HCID 68565070 | — |
| Product | [5-(1-Isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-[4-(2,2,2-trifluoro-ethanesulfonyl)-piperazin-1-yl]-methanone | HCID 68565366 | — |
Reaction Steps
The title compound was prepared in analogy to example 51, from [5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-piperazin-1-yl-methanone dihydrochloride and 2,2,2-trifluoro-ethanesulfonyl chloride. Off-white solid. MS (m/z): 517.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07507736B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-c0ac151c3c9346e78b992cda606a1a94 |
| Source note | uspto-grants-2009_03 |