Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Oxalyl chloride → benzyl 3-(chlorocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 1-((Benzyloxy)carbonyl)piperidine-3-carboxylic acid | HCID 234339 | — |
| 촉매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | benzyl 3-(chlorocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate | HCID 2776575 | — |
반응 단계
To an ice cooled methylene chloride solution of 1-[(Benzyloxy)carbonyl]piperidine-3-carboxylic acid (512 mg, 1.95 mmol) under nitrogen was added oxalyl chloride (0.185 mL, 1.95 mmol) and a few drops N,N-dimethylformamide. The reaction flask was warmed slowly to room temperature and after 2 hours the solvent was removed in vacuo. Toluene was added and removed in vacuo (2×) to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741322B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-41058c22e6b04ecb9835b0c445873296 |
| 출처 메모 | uspto-grants-2010_06 |