2-Propanesulfonyl chloride → HCID 68562525, compound

HRID 1786500Notes

Reaction equation

HRID 1786500 reaction equation
Cl.[CH:2]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH:15]3[CH2:20][CH2:19][N:18]([CH:21]([CH3:23])[CH3:22])[CH2:17][CH2:16]3)=[CH:11][CH:12]=2)[CH:7]=[C:6]1[C:24]([N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)=[O:25])([CH3:4])[CH3:3].[CH3:32][CH:33]([S:35](Cl)(=[O:37])=[O:36])[CH3:34]>>[CH:2]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH:15]3[CH2:20][CH2:19][N:18]([CH:21]([CH3:23])[CH3:22])[CH2:17][CH2:16]3)=[CH:11][CH:12]=2)[CH:7]=[C:6]1[C:24]([N:26]1[CH2:27][CH2:28][N:29]([S:35]([CH:33]([CH3:34])[CH3:32])(=[O:37])=[O:36])[CH2:30][CH2:31]1)=[O:25])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 824082-Propanesulfonyl chlorideHCID 68565609HCID 68565609, compound

Product 1

HCID 68562525HCID 68562525, compound

Procedure

The title compound was prepared in analogy to example 51, from [1-isopropyl-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-piperazin-1-yl-methanone hydrochloride and 2-propanesulfonyl chloride. Off-white solid. MS (m/z): 519.3 (M+H)+.

Sources & evidence

ORD record
ord-5120230619c8480f96c7be153d77ec80
Source dataset
uspto-grants-2009_03
Patent number
US07507736B2

Reaction notes

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