HRID1786502

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID74242

2,2,2-Trifluoroethanesulfonyl chloride

C2H2ClF3O2S

结构：CC(C)N1CCC(Oc2ccc3c(c2)cc(C(=O)N2CCNCC2)n3C(C)C)CC1.Cl

HCID68565609

未命名化合物

PRODUCTS

生成物

结构：CC(C)N1CCC(Oc2ccc3c(c2)cc(C(=O)N2CCN(S(=O)(=O)CC(F)(F)F)CC2)n3C(C)C)CC1

HCID68562514

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to example 51, from [1-isopropyl-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-piperazin-1-yl-methanone hydrochloride and 2,2,2-trifluoro-ethanesulfonyl chloride. Off-white solid. MS (m/z): 559.4 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5dd32515a0e04f91ae30da32c08171de
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07507736B2
来源说明: uspto-grants-2009_03

反应 SMILES

Cl.[CH:2]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH:15]3[CH2:20][CH2:19][N:18]([CH:21]([CH3:23])[CH3:22])[CH2:17][CH2:16]3)=[CH:11][CH:12]=2)[CH:7]=[C:6]1[C:24]([N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)=[O:25])([CH3:4])[CH3:3].[F:32][C:33]([F:40])([F:39])[CH2:34][S:35](Cl)(=[O:37])=[O:36]>>[CH:2]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH:15]3[CH2:20][CH2:19][N:18]([CH:21]([CH3:23])[CH3:22])[CH2:17][CH2:16]3)=[CH:11][CH:12]=2)[CH:7]=[C:6]1[C:24]([N:26]1[CH2:27][CH2:28][N:29]([S:35]([CH2:34][C:33]([F:40])([F:39])[F:32])(=[O:37])=[O:36])[CH2:30][CH2:31]1)=[O:25])([CH3:3])[CH3:4]