Trifluoromethanesulfonyl chloride → HCID 68563927, compound

HRID 1786506Notes

Reaction equation

Cl.[CH:2]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH:15]3[CH2:20][CH2:19][N:18]([CH:21]([CH3:23])[CH3:22])[CH2:17][CH2:16]3)=[CH:11][CH:12]=2)[CH:7]=[C:6]1[C:24]([N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)=[O:25])([CH3:4])[CH3:3].[F:32][C:33]([F:39])([F:38])[S:34](Cl)(=[O:36])=[O:35]>>[CH:2]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH:15]3[CH2:20][CH2:19][N:18]([CH:21]([CH3:23])[CH3:22])[CH2:17][CH2:16]3)=[CH:11][CH:12]=2)[CH:7]=[C:6]1[C:24]([N:26]1[CH2:27][CH2:28][N:29]([S:34]([C:33]([F:39])([F:38])[F:32])(=[O:36])=[O:35])[CH2:30][CH2:31]1)=[O:25])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 79000Trifluoromethanesulfonyl chloride

HCID 68565609HCID 68565609, compound

Product 1

HCID 68563927HCID 68563927, compound

Procedure

The title compound was prepared in analogy to example 51, from [1-isopropyl-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-piperazin-1-yl-methanone hydrochloride and trifluoromethanesulfonyl chloride. Light-yellow solid. MS (m/z): 545.3 (M+H)+.

Sources & evidence

ORD record: ord-07a967d2170243e8be4f2abc93e1bedd
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07507736B2

Reaction notes

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