HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropyl diazene-1,2-dicarboxylate → Ethyl 5-[1-(2,2,2-trifluoro-ethyl)-piperidin-4-yloxy]-1H-indole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| Reactant | Ethyl 5-hydroxy-1H-indole-2-carboxylate | HCID 90677 | — |
| Reactant | 1-(2,2,2-Trifluoroethyl)piperidin-4-ol | HCID 43426278 | — |
| Product | Ethyl 5-[1-(2,2,2-trifluoro-ethyl)-piperidin-4-yloxy]-1H-indole-2-carboxylate | HCID 68565990 | — |
Reaction Steps
The title compound was prepared in analogy to example 40d), from ethyl 5-hydroxyindole-2-carboxylate and 1-(2,2,2-trifluoro-ethyl)piperidin-4-ol, using diisopropyl azodicarboxylate instead of diethyl azodicarboxylate. Off-white solid. MS (m/z): 371.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07507736B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-678c86ed5e184ea29bab85536d9aef8e |
| Source note | uspto-grants-2009_03 |