Acetic Anhydride → 3-CHLOROPHENYL ACETATE

Participants

Reaction Conditions

Reaction Steps

3-Chlorophenol (100 g, 0.78 mol) was dissolved in acetic anhydride (75 mL, 0.8 mol). Upon addition of 1 drop of concentrated sulfuric acid, the temperature raised to 120° C. After 45 minutes, the mixture was cooled and poured into a solution of sodium hydrogenocarbonate (8 g in 1 L of water) and extracted with diethylether. The organic layer was washed with a saturated sodium hydrogenocarbonate solution, dried over magnesium sulfate and evaporated under reduced pressure. The resulting oil was used directly in the next step (84%). IR (KBr): υ: 3072 (C—H aromatic), 2939 (C—H aliphatic), 1773 (C═O), 1196 (C—O) cm−1.

Provenance & Evidence