Succinyl chloride → HCID 22395332, compound

HRID 1786531Notes

Reaction equation

HRID 1786531 reaction equation
[NH2:1][C:2]1[O:3][C:4]2[C:9]([CH:10]([C:14]3[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([Br:24])[CH:15]=3)[C:11]=1[C:12]#[N:13])=[CH:8][CH:7]=[C:6]([N:25]([CH3:27])[CH3:26])[CH:5]=2.[C:28](Cl)(=[O:34])[CH2:29][CH2:30][C:31](Cl)=[O:32]>>[C:12]([C:11]1[CH:10]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([Br:24])[CH:15]=2)[C:9]2[C:4](=[CH:5][C:6]([N:25]([CH3:27])[CH3:26])=[CH:7][CH:8]=2)[O:3][C:2]=1[N:1]1[C:31](=[O:32])[CH2:30][CH2:29][C:28]1=[O:34])#[N:13]

Participants

3

Reactant 2

HCID 10970Succinyl chlorideHCID 101597582-amino-4-(3-bromo-4,5-dimethoxyphenyl)-7-(dimethylamino)-4H-chromene-3-carbonitrile

Product 1

HCID 22395332HCID 22395332, compound

Procedure

The title compound was prepared from 2-amino-3-cyano-7-dimethylamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene and succinyl chloride as a yellow solid by a procedure similar to that described for Example 80. 1H NMR (CDCl3): 7.12 (d, J=1.8, 1H), 6.89-6.85 (m, 2H), 6.47 (m, 1H), 6.26 (d, J=2.7, 1H), 4.79 (s, 1H), 3.87 (s, 3H), 3.83 (s, 3H), 2.96 (s, 4H), 2.92 (s, 6H).

Sources & evidence

ORD record
ord-58f8c0ca330b4f2b9b5a9aebfe77c59f
Source dataset
uspto-grants-2009_03
Patent number
US07507762B2

Reaction notes

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