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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1786605Generated: November 2, 2026

4-(Trifluoromethoxy)phenylboronic acid → 5-Methyl-4-(4'-trifluoromethoxy-biphenyl-4-yloxymethyl)-furan-2-carboxylic acid

https://huagongshe.com/reaction/1786605

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethoxy)phenylboronic acidHCID 2734386—
Reactant4-(4-Iodo-phenoxymethyl)-5-methyl-furan-2-carboxylic acidHCID 18444654—
Product5-Methyl-4-(4'-trifluoromethoxy-biphenyl-4-yloxymethyl)-furan-2-carboxylic acidHCID 18444607—

Reaction Steps

Compound (114) was prepared from compound (26) and (4-trifluoromethoxy-phenyl)-boronic acid by adapting the procedure of Example 27B. LC/MS System C; Rt=11.01 mins, m/z (ES−)=391 (M−H for C20H15F3O5).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07507754B2
Source datasetuspto-grants-2009_03
ORD IDord-7035b38a01324b5d8ca19f4b9f3ffd87
Source noteuspto-grants-2009_03