HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → HCID 178434316, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | (1-Benzyl-2-hydroxy-3-isobutylaminopropyl)carbamic acid tert-butyl ester | HCID 21878363 | — |
| Reactant | HCID 178434314 | HCID 178434314 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178434316 | HCID 178434316 | 99.5% |
Reaction Steps
To (1-Benzyl-2-hydroxy-3-isobutylamino-propyl)-carbamic acid tert-butyl ester 15 (60 mg, 0.18 mmol) and 3-methyl-1H-indazole-5-sulfonyl chloride (50 mg, 0.22 mmol) in 2 mL dichloromethane was added a 70 ul solution of a saturated NaHCO3 and 30 mg NaHCO3 and stirred overnight. The product was purified by preparative TLC using 1:1 ethyl acetate: hexane to give 95 mg product (99% yield). MS 531 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07507763B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-b6c91dcf2f8c47799cd42b39bfc4aba8 |
| Source note | uspto-grants-2009_03 |