反应详情

To chlorosulfonic acid (0.38 ml, 5.7 mmol) under a blanket of argon in an ice bath was added 1-(3-methyl-indazol-1-yl)-ethanone (200 mg, 1.1 mmol). The reaction was allowed to warm to RT and then was heated at 70° C. for 45 min. The reaction was cooled to rt, slowly quenched over ice and extracted with dichloromethane. The organic phase was dried over MgSO4 and concentrated in vacuo to a tan solid (160 mg, 0.7 mmol, 61% yield).

1. temperaturewas heated at 70° C. for 45 min
2. temperatureThe reaction was cooled to rt
3. customslowly quenched over ice
4. extractionextracted with dichloromethane
5. dry with materialThe organic phase was dried over MgSO4