Chlorosulfonic acid → HCID 59717794, compound

HRID 1786656Notes

Reaction equation

HRID 1786656 reaction equation
[Cl:1][S:2]([OH:5])(=O)=[O:3].[Br:6][CH2:7][C:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[O:10][N:9]=1>>[Br:6][CH2:7][C:8]1[C:12]2[CH:13]=[C:14]([S:2]([Cl:1])(=[O:5])=[O:3])[CH:15]=[CH:16][C:11]=2[O:10][N:9]=1

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 34991891,2-Benzisoxazole, 3-(bromomethyl)-

Product 1

HCID 59717794HCID 59717794, compoundYield 80.2%

Conditions

Temperature
90 °C

Procedure

Chlorosulfonic acid (1.5 ml, 22 mmol) was slowly added to 3-Bromomethyl-benzo[d]isoxazole (1.0 g, 4.7 mmol) at RT under argon. The reaction was heated at 90° C. for 12 h and then left at RT for 6 h. The resulting viscous oil was quenched over ice, extracted with EtOAc, dried over MgSO4 and concentrated in vacuo to a brown oil (1.17 g, 80% yield).

Workup

  1. customThe resulting viscous oil was quenched over ice
  2. extractionextracted with EtOAc
  3. dry with materialdried over MgSO4

Sources & evidence

ORD record
ord-ce9520244ed44683b5e5b9d1e3bd3a1b
Source dataset
uspto-grants-2009_03
Patent number
US07507763B2

Reaction notes

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