HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1786664Generated: October 27, 2026
Phosphorus oxychloride → 3-Chloro-6-(pyridin-4-yl)pyridazine
https://huagongshe.com/reaction/1786664
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-(Pyridin-4-yl)pyridazin-3(2H)-one | HCID 2727612 | — |
| Product | 3-Chloro-6-(pyridin-4-yl)pyridazine | HCID 13059428 | 64.6% |
Reaction Steps
75.6 g 6-Pyridin-4-yl-2H-pyridazin-3-one is added in small portions to 234.5 g phosphorus oxychloride and the resulting mixture is stirred for 1 h at 100° C. Diluting into ice cold water, adjusting the pH 7 with aqueous sodium hydroxide and extraction with dichloromethane yielded 54 g 3-Chloro-6-pyridin-4-yl-pyridazine which is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07507734B2 |
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| Source dataset | uspto-grants-2009_03 |
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| ORD ID | ord-df293d8948ca4d669724f7c80cc987c5 |
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| Source note | uspto-grants-2009_03 |
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