反应详情

22 mg 4-(1H-Indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one is suspended in 30 mL acetone and 2 mg N-bromosuccinimide is added. The reaction mixture is stirred for 3 hours at room temperature, the precipitated product isolated by filtration and washed with acetone. The product is purified by preparative RP-HPLC eluting with a gradient of 0-100% acetonitrile in water (0.05% HCOOH). Yield 11.2 mg. LC-MS (ES+) 368 (M+H)+.

1. customthe precipitated product isolated by filtration
2. washwashed with acetone
3. customThe product is purified by preparative RP-HPLC
4. washeluting with a gradient of 0-100% acetonitrile in water (0.05% HCOOH)