N-Iodosuccinimide → 4-(3-Iodo-1H-indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one

HRID 1786698Notes

Reaction equation

HRID 1786698 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]1[C:11](=[O:22])[NH:12][N:13]=[C:14]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH:15]=1.C1C(=O)N([I:30])C(=O)C1>CC(C)=O>[I:30][C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][C:2]=1[C:10]1[C:11](=[O:22])[NH:12][N:13]=[C:14]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH:15]=1

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 1356875534-(1H-Indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one

Product 1

HCID 1354144544-(3-Iodo-1H-indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

577 mg 4-(1H-Indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one is suspended in 30 mL acetone and 550 mg NIS is added. The reaction mixture is stirred for 3 hours at room temperature, the precipitated product isolated by filtration and washed with acetone. The material product is used without further purification

Workup

  1. customthe precipitated product isolated by filtration
  2. washwashed with acetone
  3. customThe material product is used without further purification

Sources & evidence

ORD record
ord-f3bd3399003a4e82aa52d47a4c9b99e2
Source dataset
uspto-grants-2009_03
Patent number
US07507734B2

Reaction notes

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