(+/-)-Benzyl 3-(6-methoxy-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)piperidine-1-carboxylate → (+/-)-6-Methoxy-2-methyl-4-phenyl-3-piperidin-3-ylisoquinolin-1(2H)-one

Participants

Reaction Steps

To an ethanol (15 mL) solution of (±)-benzyl 3-(6-methoxy-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)piperidine-1-carboxylate (201 mg, 0.417 mmol) in a Parr hydrogenation jar was added 10% palladium on carbon catalyst (50 mg). The contents of the jar were hydrogenated at 60 psi for four hours. Filtration through celite followed by evaporation of the filtrate in vacuo gave the titled product as a white foam. Proton NMR for the product was consistent with the titled compound. ESI+MS: 349.2 [M+H]+.

Provenance & Evidence