Benzenamine, 3-bromo-4-methyl- → N-(3-bromo-4-methyl-phenyl)4-(4-methyl-piperazin-1-ylmethyl)-benzamide

Participants

Role	Name	HCID	Charge
Reactant	Benzenamine, 3-bromo-4-methyl-	HCID 82187	—
Reactant	Methyl 4-((4-methylpiperazin-1-yl)methyl)benzoate	HCID 782222	—
Product	N-(3-bromo-4-methyl-phenyl)4-(4-methyl-piperazin-1-ylmethyl)-benzamide	HCID 10309714	—

Reaction Steps

Yet another process, described in Scheme 3, comprises reacting 3-bromo-4-methyl-aniline with 4-(4-methyl-piperazin-1-ylmethyl)-benzoic acid methyl ester to obtain N-(3-bromo-4-methyl-phenyl)-4-(4-methyl-piperazin-1-ylmethyl)-benzamide. The latter is reacted with 4-(3-pyridyl)-2-pyrimidine amine (which is obtained by reacting cyanamide with 3-dimethylamino-1-pyridin-3-yl-propenone) to obtain Imatinib

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07507821B2
Source dataset	uspto-grants-2009_03
ORD ID	ord-e436ac9eddd74505a2e8805f5065c111
Source note	uspto-grants-2009_03