HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-5-Nitroaniline → 2-(2-Methyl-5-nitroanilino)-4-(3-pyridyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-5-Nitroaniline | HCID 7444 | — |
| Reactant | 2-Chloro-4-(pyridin-3-yl)pyrimidine | HCID 11805543 | — |
| Product | 2-(2-Methyl-5-nitroanilino)-4-(3-pyridyl)pyrimidine | HCID 10686149 | — |
Reaction Steps
Thus, Imatinib is obtained by a synthetic route comprising reacting 2-chloro-4-(3-pyridyl)-pyrimidine with 2-amino-4-nitro-toluene to obtain N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine, which is subsequently reduced and reacted with 4-(4-methyl-piperazine-1-ylmethyl)-benzoyl chloride to yield the final product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07507821B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-8725b9be91ba463d97f26d5b8682a8f5 |
| Source note | uspto-grants-2009_03 |