HCID 7195215, compound → 2,alpha-Dichlorophenyl acetic acid-(R)-2-(1-pyrrolidinyl)-1-phenylethyl ester

Participants

Reaction Steps

A solution of 5.7 g of (R)-1-phenyl-2-(1-pyrrolidinyl)-ethanol in 25 ml of tetrahydrofurane was added to a solution of 6.5 g of 2,α-dichlorophenyl acetyl chloride in 25 ml of tetrahydrofurane containing 0.9 g of 4-dimethylamine pyridine. According to a similar procedure as in example 3, a mixture of diastereomeric esters containing 72% (R,R) and 28% (R,S) of the product in a yield of 8.4 g (74%) was obtained.

Provenance & Evidence