HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxylamine → (-)-2-(Dimethylamino)-1-phenylethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxylamine | HCID 787 | — |
| Reactant | 2-(Dimethylamino)-1-phenylethanol | HCID 120846 | — |
| Reactant | HCID 7195215 | HCID 7195215 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (-)-2-(Dimethylamino)-1-phenylethanol | HCID 120844 | — |
Reaction Steps
Racemic 2-dimethylamino-1-phenyl ethanol was cleaved in accordance with the 2-pyrrolidinyl-1-phenyl ethanol (see example 6) using 16.5 g of crude amino alcohol as described in example 8. The yield of oily (R)-2-dimethyl-amino-1-phenyl ethanol with a [αD20] value of −45.5° (methanol) was 8.9 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07507827B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-735eeb16aa944771b06909321c4eb700 |
| Source note | uspto-grants-2009_03 |