Sodium Hydroxide → HCID 178493213, compound

HRID 1786728Notes

Reaction equation

HRID 1786728 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:25])[F:24])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[OH-].[Na+:28]>C(O)CCC>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[N-:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:24])[F:25])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[Na+:28]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178493214Pantoprazole

Product 1

HCID 178493213HCID 178493213, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

Pantoprazole (5.0 g, 12.8 mmol) and 98.5% NaOH (0.52 g, 12.8 mmol) were dissolved in 1-butanol (10.0 ml) at room temperature and the solution was stirred overnight at room temperature. The solution was cooled in a refrigerator and then stirred at room temperature until crystallization occurred. The crystals were filtered and dried at 50° C. under 10 mm Hg vacuum overnight to afford pantoprazole sodium Form V as determined by PXRD.

Workup

  1. temperatureThe solution was cooled in a refrigerator
  2. stirringstirred at room temperature until crystallization
  3. filtrationThe crystals were filtered
  4. customdried at 50° C. under 10 mm Hg vacuum overnight

Sources & evidence

ORD record
ord-ee860321d9234dfc9df03d96e37fd037
Source dataset
uspto-grants-2009_03
Patent number
US07507829B2

Reaction notes

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