反应详情

Pantoprazole (5.0 g, 12.8 mmol) and 98.5% NaOH (0.52 g, 12.8 mmol) were dissolved in 1-butanol (10.0 ml) at room temperature and the solution was stirred overnight at room temperature. The solution was cooled in a refrigerator and then stirred at room temperature until crystallization occurred. The crystals were filtered and dried at 50° C. under 10 mm Hg vacuum overnight to afford pantoprazole sodium Form V as determined by PXRD.

1. temperatureThe solution was cooled in a refrigerator
2. stirringstirred at room temperature until crystallization
3. filtrationThe crystals were filtered
4. customdried at 50° C. under 10 mm Hg vacuum overnight