HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → N-[2-(aminomethyl)-4-bromophenyl]pyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | N-(4-bromo-2-cyanophenyl)pyridine-2-carboxamide | HCID 57598297 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-[2-(aminomethyl)-4-bromophenyl]pyridine-2-carboxamide | HCID 57598296 | 95.7% |
Reaction Steps
2-2 (3 g, 0.0099 moles) was immediately taken up in a solution of 2.0M ammonia in methanol. To this solution was added catalytic Raney nickel. The reaction was stirred with a hydrogen balloon attached until complete by TLC. Upon completion, the reaction was filtered and the solvent was removed yielding 2.9 grams of 2-3. Analytical LCMS: (CH3CN/H2O/1% TFA, 4 min gradient), 95% pure, M+1 peak m/e 306.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07507836B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-d09384f53a9941fa81cb1e59be5567db |
| Source note | uspto-grants-2009_03 |