HCID 18770993, compound → HCID 18770915, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 4-(4-methylphenyl)spiro[2H-1-benzopyran-2,4′-piperidine]-1′-acetate (730 mg, 0.194 mmol) in ethyl alcohol (125 cm3) was added 10% palladium on carbon. This mixture was heated to 40° C. for 7 h under an atmosphere of hydrogen (4 bar) and then it was filtered whilst still warm and the filter cake was washed with hot ethyl alcohol (3×50 cm3). The solvent was removed in vacuo and the resulting compound was recrystallised from ethyl alcohol (67%). This ester was hydrolysed according to the procedure in Example 1; m.p. 247-249° C.; (M+H)+ =352.2.

Provenance & Evidence