Lithium Hydroxide → 2-(4-Cyano-3-trifluoromethyl-phenoxy)-4-methyl-pentanoic acid

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Reaction Steps

An admixture of 2-(4-cyano-3-trifluoromethyl-phenoxy)-4-methyl-pentanoic acid isopropyl ester (1A) (0.22 g, 0.67 mmol in 20 ml of dry tetrahydrofuran “THF”), LiOH (0.28 g, 6.7 mmol) and water (20 ml) is refluxed at 100° C. for 3 hours, then it is cooled to room temperature, the THF is removed, the crude product is diluted with 100 ml of ethyl acetate, and HCl(1N) to adjusted PH=1. The organic layer is separated and dried on vacuum to get the desired product.

Provenance & Evidence