Methyl iodide → 2,3-Dihydroxy-N,N,N-trimethylpropan-1-aminium iodide

HRID 1786837Notes

Reaction equation

HRID 1786837 reaction equation
[CH3:1][N:2]([CH3:8])[CH2:3][CH:4]([OH:7])[CH2:5][OH:6].[CH3:9][I:10]>C(Cl)Cl>[I-:10].[OH:7][CH:4]([CH2:5][OH:6])[CH2:3][N+:2]([CH3:9])([CH3:8])[CH3:1]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 790783-(Dimethylamino)-1,2-propanediol

Product 1

HCID 187059292,3-Dihydroxy-N,N,N-trimethylpropan-1-aminium iodideYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 1 mol of 3-(dimethylamino)-1,2-propanediol 20 (1.2 g) dissolved in CH2Cl2 (5 mL), MeI (2 g, 1.5 mol) was added and the mixture stirred at rt for 1 h. The solution was then filtered and the filtrated recristalise in MeOH/Ether and dried in vacuo. (yield 100%). The characterization data were consistent with the proposed structure.

Workup

  1. filtrationThe solution was then filtered
  2. dry with materialthe filtrated recristalise in MeOH/Ether and dried in vacuo

Sources & evidence

ORD record
ord-1cedecc8418f46aa933e6e0e4a7420d3
Source dataset
uspto-grants-2009_03
Patent number
US07507859B2

Reaction notes

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