反应详情

温度

80 °C

Under ice-cooling, thionyl chloride (8.02 mL) was added dropwise to ethanol (200 mL), and 2-fluoro-5-nitrobenzoic acid (13.81 g) was added. This mixture was stirred at 80° C. for 4 hrs. and concentrated under reduced pressure. A saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture and the mixture was extracted with ethyl acetate. The extract washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the title compound (15.77 g) as a pale-yellow oil.

1. temperatureUnder ice-cooling
2. additionwas added
3. concentrationand concentrated under reduced pressure
4. additionA saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture
5. extractionthe mixture was extracted with ethyl acetate
6. washThe extract washed with saturated brine
7. dry with materialdried over anhydrous magnesium sulfate
8. customThe solvent was evaporated under reduced pressure