2,3,5-Trimethylphenol → 1-(4-Methylphenyl)-2-(2,3,5-trimethylphenoxy)ethanone

HRID 1787141Notes

Reaction equation

HRID 1787141 reaction equation
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([CH3:9])=[CH:4][C:3]=1[OH:10].Br[CH2:12][C:13]([C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=1)=[O:14]>CO>[CH3:21][C:18]1[CH:19]=[CH:20][C:15]([C:13](=[O:14])[CH2:12][O:10][C:3]2[CH:4]=[C:5]([CH3:9])[CH:6]=[C:7]([CH3:8])[C:2]=2[CH3:1])=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 127692,3,5-TrimethylphenolHCID 692722-Bromo-4'-methylacetophenone

Product 1

HCID 231142401-(4-Methylphenyl)-2-(2,3,5-trimethylphenoxy)ethanoneYield 75%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using 2,3,5-trimethylphenol and 2-bromo-1-(4-methylphenyl)ethanone, the title compound was synthesized in the same manner as in Reference Example 159. Yield 75%. Melting point: 94-95° C. (methanol).

Sources & evidence

ORD record
ord-a8f8409b65894cb8876433e12a2fb0d2
Source dataset
uspto-grants-2009_03
Patent number
US07507841B2

Reaction notes

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