HCID 23114244, compound → HCID 23113856, compound

HRID 1787230Notes

Reaction equation

HRID 1787230 reaction equation
O[CH:2]([C:5]1[C:13]2[O:12][CH2:11][CH:10]([C:14]3[CH:19]=[CH:18][C:17]([CH:20]([CH3:22])[CH3:21])=[CH:16][CH:15]=3)[C:9]=2[C:8]([CH3:23])=[C:7]([NH:24][C:25](=[O:31])[CH2:26][C:27]([CH3:30])([CH3:29])[CH3:28])[C:6]=1[CH3:32])[CH2:3][CH3:4]>C(OCC)(=O)C.CCCCCC>[CH:20]([C:17]1[CH:18]=[CH:19][C:14]([CH:10]2[C:9]3[C:8]([CH3:23])=[C:7]([NH:24][C:25](=[O:31])[CH2:26][C:27]([CH3:28])([CH3:30])[CH3:29])[C:6]([CH3:32])=[C:5]([CH2:2][CH2:3][CH3:4])[C:13]=3[O:12][CH2:11]2)=[CH:15][CH:16]=1)([CH3:21])[CH3:22]

Participants

3

Reactant 1

HCID 23114244HCID 23114244, compound

Product 1

HCID 23113856HCID 23113856, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using a diastereo mixture of N-(7-(1-hydroxypropyl)-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-3,3-dimethylbutanamide obtained in the synthesis in Examples 30 and 31, the title compound was synthesized in the same manner as in Example 23. Yield: 86%. Melting point: 145-148° C. (ethyl acetate-hexane).

Workup

  1. customobtained in the synthesis in Examples 30 and 31

Sources & evidence

ORD record
ord-aec32b36ee7e48d7a3b185ae7add2df2
Source dataset
uspto-grants-2009_03
Patent number
US07507841B2

Reaction notes

Loading…