Chloroform → HCID 68706693, compound

HRID 1787233Notes

Reaction equation

HRID 1787233 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C@@H:10]2[C:14]3[C:15]([CH3:21])=[C:16]([NH2:20])[C:17]([CH3:19])=[CH:18][C:13]=3[O:12][CH2:11]2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].C([O:25][CH2:26][CH3:27])(=O)C.CCC[CH2:31][CH2:32][CH3:33].[CH:34](Cl)(Cl)Cl>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([C@@H:10]2[C:14]3[C:15]([CH3:21])=[C:16]([NH:20][C:26](=[O:25])[CH2:27][C:32]([CH3:31])([CH3:33])[CH3:34])[C:17]([CH3:19])=[CH:18][C:13]=3[O:12][CH2:11]2)=[CH:8][CH:9]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 6212ChloroformHCID 21226206Ethyl acetate hexaneHCID 52935173HCID 52935173, compound

Product 1

HCID 68706693HCID 68706693, compoundYield 93%

Procedure

Using (+)-(3R)-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-amine obtained in Reference Example 141, the title compound was synthesized in the same manner as in Example 1. Yield: 93%. Melting point: 148-149° C. (ethyl acetate-hexane). [α]D20=+93.2° (c=0.54, chloroform).

Workup

  1. customobtained in Reference Example 141

Sources & evidence

ORD record
ord-34d8a8d328e844418488009b05d12120
Source dataset
uspto-grants-2009_03
Patent number
US07507841B2

Reaction notes

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