Ethyl acetate hexane → HCID 68710233, compound

HRID 1787240Notes

Reaction equation

HRID 1787240 reaction equation
[C:1]([NH:5][C:6]([NH:8][C:9]1[C:10]([CH3:30])=[C:11]([CH:28]=[O:29])[C:12]2[O:16][CH2:15][C@H:14]([C:17]3[CH:22]=[CH:21][C:20]([CH:23]([CH3:25])[CH3:24])=[CH:19][CH:18]=3)[C:13]=2[C:26]=1[CH3:27])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OCC)(=O)C.CCCCCC>C(Cl)(Cl)Cl>[C:1]([NH:5][C:6]([NH:8][C:9]1[C:10]([CH3:30])=[C:11]([CH2:28][OH:29])[C:12]2[O:16][CH2:15][C@H:14]([C:17]3[CH:18]=[CH:19][C:20]([CH:23]([CH3:25])[CH3:24])=[CH:21][CH:22]=3)[C:13]=2[C:26]=1[CH3:27])=[O:7])([CH3:3])([CH3:2])[CH3:4]

Participants

4

Reactant 2

HCID 21226206Ethyl acetate hexaneHCID 86612352HCID 86612352, compound

Product 1

HCID 68710233HCID 68710233, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Using (−)-N-(tert-butyl)-N′-((3R)-7-formyl-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)urea obtained in Example 48, the title compound was synthesized in the same manner as in Example 21. Yield: 97%. Melting point: 187-188° C. (ethyl acetate-hexane). [α]D20+34.0° (c=0.43, chloroform).

Sources & evidence

ORD record
ord-7db3b81da5984279a05942288290e08e
Source dataset
uspto-grants-2009_03
Patent number
US07507841B2

Reaction notes

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