(3-Ethoxycarbonylphenyl)boronic acid → HCID 23114341, compound

HRID 1787272Notes

Reaction equation

HRID 1787272 reaction equation
Br[C:2]1[C:10]2[O:9][CH2:8][CH:7]([C:11]3[CH:16]=[CH:15][C:14]([CH:17]([CH3:19])[CH3:18])=[CH:13][CH:12]=3)[C:6]=2[C:5]([CH3:20])=[C:4]([NH:21][C:22](=[O:28])[CH2:23][C:24]([CH3:27])([CH3:26])[CH3:25])[C:3]=1[CH3:29].[CH2:30]([O:32][C:33]([C:35]1[CH:36]=[C:37](B(O)O)[CH:38]=[CH:39][CH:40]=1)=[O:34])[CH3:31]>>[CH3:25][C:24]([CH3:27])([CH3:26])[CH2:23][C:22]([NH:21][C:4]1[C:3]([CH3:29])=[C:2]([C:39]2[CH:40]=[C:35]([CH:36]=[CH:37][CH:38]=2)[C:33]([O:32][CH2:30][CH3:31])=[O:34])[C:10]2[O:9][CH2:8][CH:7]([C:11]3[CH:16]=[CH:15][C:14]([CH:17]([CH3:19])[CH3:18])=[CH:13][CH:12]=3)[C:6]=2[C:5]=1[CH3:20])=[O:28]

Participants

3

Reactant 2

HCID 3249312(3-Ethoxycarbonylphenyl)boronic acidHCID 23113867N-(7-Bromo-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-3,3-dimethylbutanamide

Product 1

HCID 23114341HCID 23114341, compoundYield 63%

Procedure

Using N-(7-bromo-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-3,3-dimethylbutanamide obtained in Example 35 and 3-(ethoxycarbonyl)phenylboronic acid, the title compound was obtained in the same manner as in Example 107. Yield: 63%. Melting point: 175-177° C. (ethyl acetate-hexane).

Sources & evidence

ORD record
ord-7ecad4b0e208491db2bd483b7e9da673
Source dataset
uspto-grants-2009_03
Patent number
US07507841B2

Reaction notes

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