3-Bromo-N,N-dimethylaniline → HCID 11225764, compound

HRID 1787279Notes

Reaction equation

HRID 1787279 reaction equation
[CH3:1][C:2]([CH3:31])([CH3:30])[CH2:3][C:4]([NH:6][C:7]1[C:8]([CH3:29])=[C:9](B(O)O)[C:10]2[O:14][CH2:13][CH:12]([C:15]3[CH:20]=[CH:19][C:18]([CH:21]([CH3:23])[CH3:22])=[CH:17][CH:16]=3)[C:11]=2[C:24]=1[CH3:25])=[O:5].Br[C:33]1[CH:34]=[C:35]([CH:39]=[CH:40][CH:41]=1)[N:36]([CH3:38])[CH3:37]>>[CH3:37][N:36]([CH3:38])[C:35]1[CH:34]=[C:33]([C:9]2[C:10]3[O:14][CH2:13][CH:12]([C:15]4[CH:20]=[CH:19][C:18]([CH:21]([CH3:22])[CH3:23])=[CH:17][CH:16]=4)[C:11]=3[C:24]([CH3:25])=[C:7]([NH:6][C:4](=[O:5])[CH2:3][C:2]([CH3:31])([CH3:30])[CH3:1])[C:8]=2[CH3:29])[CH:41]=[CH:40][CH:39]=1

Participants

3

Reactant 2

HCID 1401023-Bromo-N,N-dimethylanilineHCID 23114225(5-((3,3-Dimethylbutanoyl)amino)-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-7-yl)boronic acid

Product 1

HCID 11225764HCID 11225764, compoundYield 77%

Procedure

Using (5-((3,3-dimethylbutanoyl)amino)-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-7-yl)boronic acid obtained in Example 116 and 3-bromo-N,N-dimethylaniline, the title compound was obtained in the same manner as in Example 107. Yield: 77%. Melting point: 197-199° C. (ethyl acetate-hexane).

Sources & evidence

ORD record
ord-41653d6f439c4b4db61be7a7a1af9298
Source dataset
uspto-grants-2009_03
Patent number
US07507841B2

Reaction notes

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