Propionyl chloride → HCID 23114125, compound

HRID 1787281Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[O:15][CH2:14][CH:13]([C:17]4[CH:22]=[CH:21][C:20]([CH:23]([CH3:25])[CH3:24])=[CH:19][CH:18]=4)[C:12]=3[C:11]([CH3:26])=[C:10]([NH:27][C:28](=[O:34])[CH2:29][C:30]([CH3:33])([CH3:32])[CH3:31])[C:9]=2[CH3:35])[CH:5]=[CH:6][CH:7]=1.[C:36](Cl)(=[O:39])[CH2:37][CH3:38]>>[CH:23]([C:20]1[CH:21]=[CH:22][C:17]([CH:13]2[C:12]3[C:11]([CH3:26])=[C:10]([NH:27][C:28](=[O:34])[CH2:29][C:30]([CH3:33])([CH3:32])[CH3:31])[C:9]([CH3:35])=[C:8]([C:4]4[CH:5]=[CH:6][CH:7]=[C:2]([NH:1][C:36](=[O:39])[CH2:37][CH3:38])[CH:3]=4)[C:16]=3[O:15][CH2:14]2)=[CH:18][CH:19]=1)([CH3:24])[CH3:25]

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 23114142HCID 23114142, compound

Product 1

HCID 23114125HCID 23114125, compoundYield 84%

Procedure

Using N-(7-(3-aminophenyl)-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-3,3-dimethylbutanamide obtained in Example 122 and propionyl chloride, the title compound was obtained in the same manner as in Example 121. Yield: 84%. Melting point: 237-239° C. (ethyl acetate-hexane).

Sources & evidence

ORD record: ord-94295ee65fbe4f3582458be16428fd22
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07507841B2

Reaction notes

Loading…