HRID1787289

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID79335

1-(5-Bromo-2-thienyl)ethan-1-one

C6H5BrOS

结构：Cc1c(NC(=O)CC(C)(C)C)c(C)c2c(c1B(O)O)OCC2c1ccc(C(C)C)cc1

HCID23114225

未命名化合物

PRODUCTS

生成物

结构：CC(=O)c1ccc(-c2c(C)c(NC(=O)CC(C)(C)C)c(C)c3c2OCC3c2ccc(C(C)C)cc2)s1

HCID23113934

未命名化合物

收率 65%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21226206

未命名化合物

PROCEDURE

实验过程

Using (5-((3,3-dimethylbutanoyl)amino)-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-7-yl)boronic acid obtained in Example 116 and 2-acetyl-5-bromothiophene, the title compound was synthesized in the same manner as in Example 107. Yield: 65%. Melting point: 157-158° C. (hexane-ethyl acetate).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9deced6416f248cbb60c1db670d69c67
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07507841B2
来源说明: uspto-grants-2009_03

反应 SMILES

[CH3:1][C:2]([CH3:31])([CH3:30])[CH2:3][C:4]([NH:6][C:7]1[C:8]([CH3:29])=[C:9](B(O)O)[C:10]2[O:14][CH2:13][CH:12]([C:15]3[CH:20]=[CH:19][C:18]([CH:21]([CH3:23])[CH3:22])=[CH:17][CH:16]=3)[C:11]=2[C:24]=1[CH3:25])=[O:5].[C:32]([C:35]1[S:36][C:37](Br)=[CH:38][CH:39]=1)(=[O:34])[CH3:33]>CCCCCC.C(OCC)(=O)C>[C:32]([C:35]1[S:36][C:37]([C:9]2[C:10]3[O:14][CH2:13][CH:12]([C:15]4[CH:20]=[CH:19][C:18]([CH:21]([CH3:22])[CH3:23])=[CH:17][CH:16]=4)[C:11]=3[C:24]([CH3:25])=[C:7]([NH:6][C:4](=[O:5])[CH2:3][C:2]([CH3:1])([CH3:30])[CH3:31])[C:8]=2[CH3:29])=[CH:38][CH:39]=1)(=[O:34])[CH3:33]