Ethanolamine → HCID 23114002, compound

HRID 1787300Notes

Reaction equation

HRID 1787300 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[C:14]3[C:15]([CH3:31])=[C:16]([NH:22][C:23](=[O:30])OCC(Cl)(Cl)Cl)[C:17]([CH3:21])=[C:18]([O:19][CH3:20])[C:13]=3[O:12][CH2:11]2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[NH2:32][CH2:33][CH2:34][OH:35]>CCCCCC.C(OCC)(=O)C>[OH:35][CH2:34][CH2:33][NH:32][C:23]([NH:22][C:16]1[C:17]([CH3:21])=[C:18]([O:19][CH3:20])[C:13]2[O:12][CH2:11][CH:10]([C:7]3[CH:8]=[CH:9][C:4]([CH:1]([CH3:2])[CH3:3])=[CH:5][CH:6]=3)[C:14]=2[C:15]=1[CH3:31])=[O:30]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 86618060HCID 86618060, compound

Product 1

HCID 23114002HCID 23114002, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using 2,2,2-trichloroethyl (3-(4-isopropylphenyl)-7-methoxy-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)carbamate obtained in Example 140 and 2-aminoethanol, the title compound was synthesized in the same manner as in Example 143. Yield: 59%. Melting point: 127-129° C. (hexane-ethyl acetate).

Sources & evidence

ORD record
ord-26660c8722254d219455ab9d1b34457a
Source dataset
uspto-grants-2009_03
Patent number
US07507841B2

Reaction notes

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